He is 5 months old. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. It is also labeled for the treatment and prevention of the Gulf Coast tick, American dog tick, black-legged tick, lone star tick, and brown dog tick. Those jaw spasms have decreased but were pretty alarming in Dec and January. So your dog got better? Any other alternatives that are not harmful? I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. Gave our 23 month old Black Lab. I will have to keep an eye out on her. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Omg, this is beyond awful and makes me so worried. Today June 1,2022 she is still having neurological problems. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. They may not be ready to beat you in a game of chess, but these brainy dogs are easy to train and generally eager to please you. Any response from the company? I can tell something is off with her I just couldnt figure it out. Please do not use this drug. How is your cockapoo doing now? If I still lived in the city, I would probably use the garlic because the previous GS never had any issues and lived a long time. I would NEVER recommend this medication. Anyway, he prescribed him pain relief for 7 days. Again our dog had a major seizure in January and we searched for a neurologist ear by. Gave my 3 year old Yorkie Simparica and 24hrs later he became hyperactive panting pacing and started hiding in dark places. I came across this site and read so much about symptoms that I now realize he has been having. If this was our children and you went to your doctor for a shot, and the Dr. said "don't worry, only 1% of kids get seizures or other problems from this shot, we wouldn't stand for it. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. Heal quickly and clumps of hair fall out. If there are enough reports they may have to pull it off the market until further safety tests can be done. I'll continue to watch her. Im done with this drug! This junk needs to be pulled from the market. She also started drinking excessively, and peeing in the house. I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. She has had tremors, very lethargic, drinking lots of water. It is the most convenient flea and tick protection product on the market. Im now scared half to death. First month, the one threw up, same thing second month. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. I give my dogs Simparica at the beginning of each month. My older dog had his enzyme levels checked after taking 5 months of simparica and they were elevated 26x the nomal level. I did and they said they are going to report it to the FDA. About 11 months ago our vet recommended Simparica Trio. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. The office girl not the vet said if it my dog threw up within one hour after eating her pill - then it is safe to give her another one. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. The neurologist I went to would not give him steroids until I did the spinal tap and MRI. PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs), 6 Doses. The following list includes the known side effects of Simparica. No seizures yet thank goodness, but he is drinking a ton of water. How is your dog doing? This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. Anyone else have the same eye issues? And a bit more stumbling. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. Hard fast shaking and terrified eyes. The next morning, she had uncontrollable tremors and could not walk without falling down. Tuesday morning she woke up with horrible diarrhea. She was being seen by her regular vet and was put on antibiotics. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. I'll be calling them tomorrow. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. Always confirm storage temperatures by reading the label. Over two weeks later she still can not walk properly. Still waiting on the vet and waiting to talk to ASPCA poison control. My dog is having seizures. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. I am so upset - I gave it to him last week and he had an accident in the house. The reason I had stopped it , I saw a Instagram where a girls dog took the. Was not too excited about it, and I really should've declined it. My nearly 14 year old Havanese Kokomo has taken a sharp decline in the last 8 month and I was blaming it on old age when I think I may have been poisoning him. Thank you. old . Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. Dogs Naturally Market is a good source to check out. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! She would constantly twirl in left circles. I say yes! I'm more concerned about fleas and heartworms and Trifexis is just fine for that. It didnt even occur to me it could be the drug as my doctor just gave individual pills and I didnt get to read side effects. I gave my dog simparica trio. I want to thank everyone who posted I could not find enough information on other sites. I wish I would have seen this site before I gave it my Matty. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. Our miniature schnauzer has been extremely thirsty and itchy to the point of biting until he bleeds. I am terrified--wish I would of seen this sooner. Her last dose of Simparica Trio was given to her on October 1, 2021. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. Simparica Trio contains three active ingredients . I quit the canned sweet potatoes (he loved them) thinking it was the syrup, that I drained anyway before adding to mixture. It can also cause seizures and tremors, but those side effects are incredibly rare. He wasnt throwing up at all until he received this medication. Eyes roll back. Nexgard can cause lethargy and a loss of appetite in dogs. My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? Also I read on Dr Mercola site that heartworms is in the dogs blood not the digestive track and garlic won't work. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. 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